Beilstein J. Org. Chem.2014,10, 3031–3037, doi:10.3762/bjoc.10.321
describe a one-pot protocol for the synthesis of a novel series of polycyclic triazole derivatives. Transition metal-catalyzed decarboxylativeCuAAC and dehydrogenative cross coupling reactions are combined in a single flask and achieved good yields of the respective triazoles (up to 97% yield). This
methodology is more convenient to produce the complex polycyclic molecules in a simple way.
Keywords: copper(II) acetate; decarboxylativeCuAAC; dehydrogenative coupling; fused triazoles; one-pot synthesis; Introduction
The copper-catalyzed Huisgen [3 + 2] cycloaddition (or copper-catalyzed azide–alkyne
organic azides. This kind of decarboxylativeCuAAC reaction has not been further investigated. Transition metal-mediated C–H bond activation has become a hot topic in recent years [7][8][9][10][11]. Formally, it requires insertion of a transition metal (usually Pd, Ru, Rh or Ir) across a strong C–H bond
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Graphical Abstract
Scheme 1:
Synthesis of polycyclic fused triazoles.